Top 10 Manchester startups (2025) — name, short note, HQ address + postcode
(addresses / postcodes cited for each entry)
- Peak (Peak AI) — AI decisioning platform for retail, supply chain and revenue optimisation.
Hyphen, 75 Mosley Street, Manchester, M2 3HR. (Peak) - Matillion — cloud data integration / ETL scale-up founded in Manchester (large Manchester office / HQ presence).
Two New Bailey, Stanley Street, Salford, Manchester, M3 5GS. (Matillion) - Arctic Shores — behavioural/psychometric assessment platform for hiring and talent measurement.
Lowry House, 17 Marble Street, Manchester, M2 3AW. (arcticshores.com) - UrbanChain — energy marketplace / local renewable-energy trading (rapid-growth scale-up from Manchester Science Park).
BASE, Manchester Science Park, Greenheys Lane, Manchester, M15 6LR. (UrbanChain) - Sourceful — sustainable packaging & supply-chain platform (packaging tech startup with Manchester HQ).
Colony, 5 Piccadilly Place, Manchester, M1 3BR. (Sourceful) - Netacea — bot-protection / fraud-defence platform (fast-growing cyber / security scale-up in the city).
Suite 5.06, Department Bonded Warehouse, 18 Lower Byrom Street, Manchester, M3 4AP. (Netacea) - Zilico — medical diagnostics / electrical impedance spectroscopy (MedTech spin-out based at Manchester Science Park).
Rutherford House, Pencroft Way, Manchester Science Park, Manchester, M15 6SZ (previously listed at this address). (Endole) - Mojo CX (t/m TMAC / Mojo-CX) — AI/automation for contact-centre / customer experience (rapidly scaling Manchester CX/AI startup).
The Express Building, 9 Great Ancoats Street, Manchester, M4 5AD. (tmac.ai) - QV Bioelectronics / QV Bio — bioelectronics start-up (implantable electrotherapy devices; Alderley Park / Manchester region address).
21 LGA, Alderley Park, Macclesfield (near Manchester), SK10 4TG. (QV Bioelectronics) - Monument Therapeutics (Monument Tx) — neuroscience / stratified-medicine biotech (Alderley Park / Macclesfield).
Block 1 – G28, Alderley Park, Congleton Road, Macclesfield, SK10 4TG. (Find and Update Company Information)
Notes on selection & accuracy
- I prioritized companies repeatedly highlighted in 2024–2025 Manchester / UK startup indexes and regional press (Seedtable, AboutManchester, StartupBlink, local business titles) and confirmed legal/contact addresses via company sites or Companies House. (seedtable.com)
- Some life-science companies list Alderley Park / Macclesfield addresses (SK10) — it’s the Greater Manchester biotech cluster and is commonly included in “Manchester startup” roundups; I included those because they appear consistently in 2025 lists. (QV Bioelectronics)
- Companies sometimes change registered-office details; I used the address shown on (a) company contact pages and (b) Companies House / official filings where available (sources cited per company). If you need absolute legal mailing addresses (for contracts / legal service) I recommend using the Companies House filing PDF (I ca
Nice — below are 10 compact case studies (one per startup) for Top Manchester startups, 2025, each including the HQ postcode, a short problem→solution case study, recent traction or notable milestone, and my short comments/advice for partners or investors. I verified company contact/registered addresses and cited key sources for each entry.
1) Peak (Peak AI) — M2 3HR
Address / postcode: Hyphen, 75 Mosley Street, Manchester, M2 3HR. (Peak)
Case study (problem → solution): Retailers and CPG firms struggled to turn fragmented sales and inventory data into profitable pricing and replenishment actions. Peak’s automated decisioning platform ingests POS, ERP and digital signals and produces prescriptive actions (pricing, promotions, stock rebalancing) applied in near real-time. Large retailers reduced stockouts and improved margin-per-SKU in pilot deployments. (Peak)
Traction / milestone: Historically Manchester-headquartered; Companies House shows a registered-office update in March 2025 (reflecting expansion/operational changes). (Find and Update Company Information)
Comment: Peak’s strength is ML-to-action — good fit for strategic pilots with mid-market retailers. Watch governance as they scale (registered-office moves can signal restructuring).
2) Matillion — M3 5GS
Address / postcode: Two New Bailey, Stanley Street, Salford, Manchester, M3 5GS. (Matillion)
Case study: Enterprises have huge cloud data stacks but limited orchestration to deliver analytics. Matillion provides cloud-native ETL/ELT tooling that simplifies ingestion and transformation for Snowflake/Databricks/Redshift. Customers report faster time-to-analytics and lower engineering overhead vs. hand-built pipelines. (Matillion)
Traction / milestone: A major Manchester-born scale-up with a global footprint; widely used by SaaS and enterprise analytics teams. (Matillion)
Comment: Matillion is a mature scale-up—ideal partner for analytics-led GTM plays; investors should focus on margins as cloud-ETL markets consolidate.
3) Arctic Shores — M2 3AW
Address / postcode: Lowry House, 17 Marble Street, Manchester, M2 3AW. (arcticshores.com)
Case study: Traditional CV/resume screening misses behavioural fit. Arctic Shores built gamified, task-based psychometric assessments that map cognitive and behavioural traits to job performance, improving early-stage screening and diversity outcomes for hiring teams. Several enterprise customers reported improved quality-of-hire in trials. (arcticshores.com)
Traction / milestone: Established since the 2010s and consistently cited in HR-tech roundups; maintains registered office details in Manchester. (CB Insights)
Comment: Strong product-market fit in regulated hiring verticals; buyers should validate A/B test results for fairness and adverse impact in their own populations.
4) UrbanChain — M15 6LR
Address / postcode: BASE, Manchester Science Park, Greenheys Lane, Manchester, M15 6LR. (UrbanChain)
Case study: Small-scale renewable generators (solar on schools, community projects) struggled to sell locally at fair value. UrbanChain created a marketplace and matching engine (plus supplier licensing) to let local generators trade energy directly with local consumers and businesses, improving producer economics and local grid balancing. (UrbanChain)
Traction / milestone: Reported rapid growth and Ofgem-level regulatory activity in 2024–25 (profiled in national business press for revenue growth and market expansion plans). (The Times)
Comment: Regulatory/regulatory-compliance is core risk/opportunity; ideal partners: municipal energy programmes and corporates exploring local renewable sourcing.
5) Sourceful — M1 3BR
Address / postcode: Colony, 5 Piccadilly Place, Manchester, M1 3BR. (Sourceful)
Case study: E-commerce brands need sustainable, cost-efficient packaging. Sourceful offers a supply-chain + sourcing platform that matches brands to sustainable materials and suppliers, automates quotes and shortens lead times. Customers lowered packaging carbon footprint and SKU packaging cost through platform-sourced alternatives. (Sourceful)
Traction / milestone: Active platform with commercial contracts and platform terms published in 2025; positioning itself as supply-chain + sustainability enabler. (Sourceful)
Comment: Strong fit for D2C brands and FMCG sustainability goals; procurement teams should run side-by-side cost + lifecycle analyses before switching suppliers.
6) Netacea — M3 4AP
Address / postcode: Suite 5.06, Department Bonded Warehouse, 18 Lower Byrom Street, Manchester, M3 4AP. (Netacea)
Case study: Online merchants suffered from credential-stuffing and automated scalper bots; Netacea created an agentless bot-protection platform to detect and mitigate malicious automation at scale. Customers see reduced fraud rates and fewer false positives compared with rule-only solutions. (Netacea)
Traction / milestone: Ongoing commercial activity and platform evolution; registered office and contact details listed publicly. (Netacea)
Comment: Cybersecurity buyers should include Netacea in bot-fraud assessments; evaluate integration complexity with existing WAF/CDN stacks.
7) Zilico — M15 6SZ (formerly listed)
Address / postcode: Rutherford House, Pencroft Way, Manchester Science Park, M15 6SZ (note: Companies House filings show address changes in 2025 — check filings if you need legal mailing address). (News-Medical)
Case study: Zilico commercialised an electrical-impedance-based diagnostic (ZedScan) for early detection of oesophageal disease and other clinical screening use-cases — giving clinicians a point-of-care adjunct to endoscopy/biopsy decisions, which can improve triage and reduce invasive tests. (UK Healthcare Pavilion)
Traction / milestone: Longstanding MedTech spin-out from Manchester Science Park; recent filings show registered-address movements in 2025. (Find and Update Company Information)
Comment: MedTech buyers and NHS partners must validate local clinical pathway integration and reimbursement models before adoption.
8) Mojo CX (TMAC / Mojo-CX) — M4 5AD
Address / postcode: The Express Building, 9 Great Ancoats Street, Manchester, M4 5AD. (tmac.ai)
Case study: Contact centres need better agent coaching and automation to handle complex omnichannel queries. Mojo-CX provides AI tooling and workflow automation to boost agent productivity and first-contact resolution, with measurable reductions in handle time in pilot deployments. (tmac.ai)
Traction / milestone: Registered at The Express Building and listed in Companies House; increasing adoption in European CX teams. (Find and Update Company Information)
Comment: Good target for enterprise CX pilots; procurement should verify data-handling and compliance for conversational AI.
9) QV Bioelectronics — SK10 4TG (Alderley Park)
Address / postcode: 21 LGA, Alderley Park, Macclesfield, SK10 4TG. (QV Bioelectronics)
Case study: QV is developing implantable electro-therapy devices based on electric-field therapy for aggressive brain tumours — aiming to complement radiotherapy/chemotherapy where conventional treatments have limited effect. Preclinical/early clinical programmes drive the R&D narrative. (QV Bioelectronics)
Traction / milestone: Active R&D company registered at Alderley Park (the Greater Manchester biotech cluster); Companies House confirms registered office in SK10. (Find and Update Company Information)
Comment: High-risk, high-reward biotech — ideal for strategic translational grants, clinical-trial partnerships, and specialist med-device investors.
10) Monument Therapeutics — SK10 4TG (Alderley Park)
Address / postcode: Block 1 – G28, Alderley Park, Congleton Road, Macclesfield, SK10 4TG. (Find and Update Company Information)
Case study: Spin-out from neuroscience/digital biomarker research, Monument focuses on neuroscience therapeutics and biomarkers for patient stratification. Their approach mixes small-molecule/biologic pipelines with digital biomarkers to improve trial readouts and speed patient selection. (Monument TX)
Traction / milestone: Registered at Alderley Park with active pipeline communications and company filings on record. (Find and Update Company Information)
Comment: Strong technical team pedigree — attractive to pharma partnerships seeking better stratification and digital endpoints in CNS trials.
Method & caveats
- I verified each company’s public contact/registered addresses from their corporate site or UK Companies House / official listings and used those pages as the primary citations above. When companies show an address change in public filings (e.g., Peak, Zilico), I flagged that — always use Companies House PDFs for legal service addresses. (Find and Update Company Information)
- For the short case studies I relied on company product pages, press profiles and business reporting — those are cited next to each company. Some claims (e.g., revenue or growth figures) are reported in press profiles and, where sensitive, I only summarised the implication (growth/market traction) rather than giving single-source financial numbers. (The Times)
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